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Bleach, which can kill drain flies, can also kill fruit flies, but it’s better to lure fruit flies to a liquid rather than applying chemicals, as it’s very difficult to reach them all. A more practical approach is to lure fruit flies with traps made from liquids like apple cider vinegar mixed with dish soap. This method is safer and more efficient, since it targets a larger number of fruit flies without relying on harsh chemicals that may not reach all the pests.

Squirrels hate not having access to secure shelter or food sources. Your best line of defense is to make your property less attractive by removing access to these things. There are chemical squirrel repellents, but these have mixed success. According to Pennsylvania State University, you can apply products containing the bittering agent denatonium saccharide to a squirrel's favorite fence, tree, or roof spots. However, you need to reapply repellents regularly, which aren’t scientifically proven effective.

Tree sap is not usually dangerous to humans or pets. But some trees do produce dangerous sap. Notably, ash, birch, cedar and similar saps can irritate the skin but aren’t dangerous. Sap from trees like the Brazilwood, Mahogany, Milky Mangrove or well-named Poison Walnut can be corrosive, cause nausea, or trigger those with asthma. But for most backyard trees, protective equipment like a sturdy pair of gloves should be fine.

Poison will kill small rodents and can seem like the quick and easy way to get rid of them. But—in addition to its inhumane nature—poison has some drawbacks. First of all, if you have small children or pets in the home, setting out poison isn't the best idea, as your pets or children could ingest it. 

Poisoned mice and rodents don't die instantly. Instead, it can take several days for the poison to work its way through their system. In the meantime, there's a chance that a predator, such as a cat, fox, or other mammal, will eat the poisoned rodent and become poisoned themselves.