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Yes, if there is mold in your drywall mud and you then use it to build walls in your house—or if mold develops in your set drywall, like it can in hot and humid areas—it can lead to illness. Mold in your drywall (or other parts of your home) can make existing respiratory conditions or allergies worse, and the effect can be more intense for those who have existing health issues or compromised immune systems.

You should stagger drywall sheets to help prevent cracking. The joints between drywall sheets are the weak spots, so if you install drywall with seams aligned, you’ll create weak lines that run across the length of the wall and extend from floor to ceiling. But when you stagger drywall, the solid sections of panels will support the joints. This can prevent seams from cracking or separating due to fluctuating temperature and humidity, vibrations from movement inside the home, and gravity.

If you’re installing new drywall, you may need to skim coat the drywall first for a smooth finish and to allow the primer to adhere to the wall. It’s only necessary if there are imperfections in your drywall due to issues with the studs or improper drywall installation. If you’re refreshing existing walls, you may want to skim coat if there are imperfections across the wall. As an alternative, you can repair your drywall and sand it for a smooth finish before painting.

While not always necessary, you can glue a drywall ceiling in addition to using screws or nails. Drywall is typically secured to ceiling joists with fasteners, which is often sufficient. However, adding construction adhesive can offer benefits like preventing sagging, bridging gaps, and reducing air leaks for better energy efficiency. It may also be used for specific acoustic or insulation needs. On the other hand, many professionals advise against it because properly placed screws make the drywall structural, glue doesn't add strength, and it makes future repairs or replacements significantly more difficult. Ultimately, it's best to follow local building codes and project-specific requirements to decide if adhesive is right for your ceiling.