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Drywall can be toxic to the environment and to humans in some cases. As drywall breaks down in a landfill and comes in contact with other organic chemicals, it can create hydrogen sulfide gas or leach into the groundwater. Additionally, the CDC recommends methods for controlling the inhalation of drywall dust when handled. While the common ingredients of drywall—gypsum, silica, and mica—are naturally occurring, they can cause irritation in some humans.

If your home was built before the 1940s and was not remodeled in the past 50 or so years, you probably have plaster walls. Aside from assuming, there are some practical ways to tell if you have plaster walls, including the following: If you knock on the wall and it feels solid, not hollow, if you can’t insert a thumbtack easily, if there are cracks that look like spiderwebs, or if your home has curved, arched, or swirled walls, doorways, or window openings.

If you have an unfinished basement or attic, you could examine the backs of any finished walls to check, too.

If you suspect black mold is inside your walls, do not punch a hole in the drywall yourself to look. Call a mold inspection expert to help you. Some signs of a potential black mold infestation inside the wall include an unexplained musty, damp smell. Some people liken it to rotting vegetables. You may smell it most strongly through a wall outlet. If you and your family are experiencing constant coughing or symptoms that feel like an unexplained allergy, it could indicate black mold behind a wall.

In framing, studs are placed at 16-inch intervals to coincide with the typical spacing of wall materials such as drywall or plywood. This spacing is called "on-center" and is necessary for maintaining structural stability and efficient use of materials. The 16-inch spacing also helps to distribute the weight evenly across the building's structure. For those looking to cut material costs and improve energy efficiency, 24-inch stud spacing can be employed through a method called "advanced framing". This requires careful planning and adherence to local building codes to ensure structural integrity.