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Smaller is better when patching holes with spackle. Any holes wider than four to six inches in diameter tend to be too wide to repair with spackle alone. You'll likely want to patch bigger holes with a drywall panel. 

Even holes measuring up to 6 inches may be challenging to fill with spackle alone. For best results, purchase a wall repair patch made from wire mesh. Cut the patch to fit over the hole, then use the spackle to hold it in place. Apply the spackle over the patch as you would for a smaller hole.

Although they have similar applications, spackle and joint compound are not the same. Their primary differences lie in their composition, consistency, and ideal use cases.

Spackle is composed of gypsum and binding agents, making it thicker than joint compound. It dries quickly and is easy to sand, which makes it ideal for small wall repair projects like filling nail holes or patching minor damage.

Joint compound, also known as drywall mud, consists of limestone and gypsum. It is primarily used for large-scale projects, such as taping and finishing the seams on newly installed drywall. It tends to shrink more than spackle and can be more difficult to spread.

While both products can be used to fill small depressions and cracks, spackle cannot replace joint compound for taping and mudding new drywall. Conversely, you can often use joint compound for small patching jobs typically done with spackle.

Technically speaking, you can use drywall primer over plasters. However, oil-based primers work the most effectively on wall plasters. Meanwhile, water-based primers work just as well with drywalls. Nowadays, there are also universal primers suitable for drywall and plaster. Overall, you will be fine as long as you are using a trustworthy brand.

Plaster provides a durable, soundproof, and moisture-resistant finish compared to drywall.