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Squirrels hate not having access to secure shelter or food sources. Your best line of defense is to make your property less attractive by removing access to these things. There are chemical squirrel repellents, but these have mixed success. According to Pennsylvania State University, you can apply products containing the bittering agent denatonium saccharide to a squirrel's favorite fence, tree, or roof spots. However, you need to reapply repellents regularly, which aren’t scientifically proven effective.

You can use a homemade spray to kill fleas on a mattress. To make the spray, combine equal parts water and distilled white vinegar. Spray the mixture on the fleas and all over the mattress. Follow this up with a generous sprinkle of salt all over the mattress, and let it sit overnight. Finally, vacuum the mattress to clean up the salt, dead fleas, and flea offspring.

Most spiders are harmless or do little more than the equivalent of a bee sting. Prevention is the best option for more serious cases. Keep spiders out of your home when possible. When you find spiders, a spider nest, or egg sac, remove it quickly before an inquisitive pet or child gets involved. When children are old enough, teach them to recognize the few dangerous species of spiders and avoid them to prevent getting bitten.

As nocturnal animals, mice are most active at night. During the day, they prefer to hide in cool, dark, and undisturbed places. Common hiding spots include spaces between walls, inside pantries and cupboards, behind sofas, and in old boxes or other clutter.