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Leaving pee on a mattress for an extended period of time will make it harder to remove the moisture, increase the likelihood of unappealing stains forming, and make the urine odor linger for a longer time. Ideally, you should start cleaning a urine-soaked mattress immediately. You can start by spraying a 1:1 solution of white distilled vinegar and water over the stain and then blotting it out. Then, sprinkle baking soda over the affected area, let it sit for 8 to 10 hours, and then vacuum it out. If the issue persists, you might need to dispose of your mattress and replace it.

Do not mix bleach with vinegar, ammonia, acidic liquids, or other cleaners or detergents as toxic fumes result from the chemical reaction. Mix bleach only with water to avoid dangerous chemical reactions. Even mixed with water to dilute it, bleach can still be harmful to your skin, eyes, and lungs.

A deep cleaning goes beyond traditional cleaning and includes tasks like cleaning grout and baseboards, organizing closets and drawers, dusting blinds and fans, and cleaning the inside and outside of appliances. It’s a much more thorough, comprehensive cleaning that focuses on hard-to-reach areas and often forgotten about spots. 

In some cases, yes, it’s safe to spray hydrogen peroxide on your mattress, but the solution can damage memory foam mattresses, so you should only use it on non-memory foam mattresses. If you have a standard spring mattress, you can mix hydrogen peroxide with cold water in a 1:1 ratio and spray that on your urine-soaked mattress. If you’re cleaning pee out of a memory foam mattress, swap out the hydrogen peroxide for white distilled vinegar, or call in a professional mattress cleaner to avoid doing damage to your mattress.