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It’s debatable, but most will say either termites or bed bugs are the hardest to remove. When dealing with termites, you must find the central nest (as opposed to satellite nests) and exterminate the queen and all potential queens, which often takes the work of a specialist. Bed bugs, meanwhile, are incredibly hardy, good at hiding, and resistant to pesticides, so it takes very careful, very thorough work to get rid of them permanently. 

The safest ways to treat bed bugs are non-chemical, such as using diatomaceous earth, essential oils, and heat and cold treatments. Heat treatments are also one of the most effective methods because it kills bed bugs at all levels of life stages: eggs, nymphs, and adults. However, you still need to take precautions by removing items that can be susceptible to heat damage. You also need to remove plants and pets from your home during treatment.

It’s not fast, but you can tightly seal items and store them away for at least a few months, preferably an entire year. Bed bugs can’t survive that long without eating. However, this method takes significantly longer than other common eradication methods like heat treatments, steaming, or fumigation, so it’s not a first choice for homeowners.

No, poison isn’t the best way to deal with animals in your attic. It’s unlikely to completely eradicate the problem, especially if you don’t take care of access points. Also, poisoned animals may die and decay in the attic, causing noxious odors. 

Some animals may leave the attic before the poison kills them, which could lead to nearby pets or other wildlife eating the animals and becoming poisoned themselves. Ultimately, it’s better to avoid using poison and contact a professional instead.