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This varies based on the circumstance. Chemical-based pest control baits and poisons are usually the most potent, but they are unsafe to use around children and pets, so they won’t be a fit for every household.

Safer alternatives, such as boric acid and food-grade diatomaceous earth, can work as well, though they should still stay out of reach. Aside from that, the best thing any DIY-er can do is make their place uninviting by sealing off entry points, eliminating clutter, and maintaining a clean home.

Many people have reported success in using dryer sheets to deter mice. This result is likely due to the strong scent that the rodents don’t find favorable. However, using dryer sheets alone may not be a foolproof solution, and it's often better to combine various preventive measures, such as traps, repellent sprays, and proper storage practices, to protect your car from rodent infestations more effectively.

Like many other rodents, squirrels can be a little difficult to get rid of (especially in the case of an infestation), but the best approach is to make the place as unattractive to squirrels as possible. If you do have an infestation inside your home, then professional help may be necessary so you can lay as many traps as possible. 

Deer rely on scent to tell them what’s safe and unsafe, so effective deer repellents have to be pungent. Make your own natural repellent by combining a beaten egg, one tablespoon of cooking oil, one tablespoon of dish soap, and a half cup of milk. Pour it into a spray bottle and spray around your garden, avoiding anything you will want to eat later. This stinky repellent will ward off any deer that want to make your produce their next meal. But keep in mind that if your windows are nearby, the scent may waft over.