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No, poison isn’t the best way to deal with animals in your attic. It’s unlikely to completely eradicate the problem, especially if you don’t take care of access points. Also, poisoned animals may die and decay in the attic, causing noxious odors. 

Some animals may leave the attic before the poison kills them, which could lead to nearby pets or other wildlife eating the animals and becoming poisoned themselves. Ultimately, it’s better to avoid using poison and contact a professional instead.

Roach spray usually starts working almost immediately on contact—within seconds to a few minutes. However, if it's a residual spray designed to keep killing over time, it can take hours or even days to fully affect roaches that come into contact with treated surfaces. For larger infestations, it may take at least a week to see a noticeable drop in activity, since not all roaches are exposed at once.

Cinnamon's warm scent appeals to many people but not to many bugs. The spice contains eugenol, which also happens to be used in insecticides. While the level of eugenol in cinnamon isn't enough to eliminate bugs on its own, the scent can be strong enough to keep them away. 

You can try sprinkling cinnamon around areas where you've seen insects, such as ants and mosquitos. Remember that you'll have to reapply frequently, especially after periods of rain.

Most spiders are harmless and are more interested in finding and eating insects than trying to bite you or your family members. Certain spiders in your home may be advantageous if you have an issue with insects. Most spiders are non-venomous and have small mouths, so even if they did bite you, it wouldn’t be enough to cause any harm.

However, some species of spiders can cause harm if you are a victim of their spider bite, including the black widow and brown recluse varieties. Both species’ venom is poisonous, and you should seek medical help if bitten.