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Glyphosate and other non-selective herbicides can kill orchard grass, but they will also kill the surrounding plants. Also, not all areas allow the use of glyphosate due to its environmental impact—which the EPA describes as a "potential risk to terrestrial and aquatic plants and birds, and low toxicity to honeybees." Consider mechanical removal to target the plants specifically.

Vinegar is known to be a contact herbicide, which means it kills the foliage it comes in contact with. Because of the high acetic acid concentration, horticultural vinegar kills weeds and grass more effectively. However, keep in mind that high amounts and multiple applications can affect the soil by lowering the pH levels.

Ultimately, pulling weeds vs. spraying them depends on what’s happening in your yard and your personal preferences. Manual weed removal doesn’t introduce any chemicals into your landscape, targets specific problematic plants, produces immediate results, can be free if you go the DIY route, and is inexpensive with a weed service if you only have a handful of weeds. On the other hand, spraying is often preferable for severe weed infestations and situations involving difficult-to-pull weeds because it treats multiple weeds at once, is usually more effective long-term, is less time-consuming, and costs less when done by a pro.

A spot herbicide for weed control is effective at killing crabgrass and not grass, but it depends on the type of herbicide. Always check the label to ensure that your herbicide is safe for grass but tough on crabgrass. Overall, spot treatment is ideal because it puts fewer herbicides into the soil, which can damage the soil. If you’re wanting a natural remedy to crabgrass that also won’t harm surrounding grass, you can also hand-remove crabgrass or even pour boiling water or 5% vinegar over crabgrass as a spot treatment.