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Luckily, skunks aren’t challenging to get rid of. You can try to remove them slowly by filling their den entryway loosely with newspaper. Many skunks notice their den is in jeopardy and take off on their own. You can also try making a homemade spray of jalapeno pepper, yellow onion, and cayenne pepper—believe it or not, skunks are sensitive to these smells, so if you spray this around the den or in hard-to-reach places around your property, most skunks will take the hint and leave. 

You don’t need heavy-duty chemicals to get rid of a bobcat. In fact, one of the most simple and effective methods of preventing bobcats from entering your property is by keeping your yard clear of overgrowth by trimming bushes and trees regularly. This eliminates potential hiding spots for a bobcat and makes them easier to spot in general.

Bed bugs typically will not go away on their own. If there are no humans or animals around, they will need to leave to find a host for feeding. But otherwise, bed bugs can live for several months to a year, and the adult females can lay hundreds more eggs in their lifetime. An infestation is only likely to get worse without hiring an exterminator.

While possums don’t typically carry rabies, they can have lice, fleas, ticks, and mites. According to the University of California’s Pest Management Program, possums can also carry diseases like leptospirosis, tuberculosis, toxoplasmosis, coccidiosis, and fevers. Possums are also the carriers of a parasite that can pass to horses and cats called Equine Protozoal Myeloencephalitis (EPM).