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While some chemical drain cleaners with hydrochloric acid can dissolve hair, this method is not recommended as it can also destroy your plumbing pipes. A common DIY alternative is using baking soda and vinegar, which can help break down the clog but will not actually dissolve the hair. The best and safest method for clearing a hair clog is to remove it manually. You can use a drain snake, a straightened wire hanger with pliers to fish out the clog, or have a plumber use a professional auger for more severe blockages.

Unlike regular cleanings, snaking your sewer line should be done as needed. There’s no reason to snake your sewer line if you don’t have any noticeable issues, like slow drainage or plugged drains. You can add it to your regular sewer cleaning checklist as a prevention method (on the same 18- to 22-month schedule), but it’s not always necessary. 

An active cleaning agent and a drain snake is the best way to clean a main sewer line. You can purchase a regular or enzyme drain cleaner or make a DIY drain cleaner with baking soda. Use your chosen solution at least once a month or as needed to keep your sewer line clear. 

As a preventative measure, hydro jetting should be done every one to two years. However, the best practice is to hydro jet your sewer line once per year. The ideal frequency depends on several factors, including the age and condition of your pipes, how prone they are to clogging, how often the sewer line is used, and the type of waste disposed of in the system. If you frequently experience clogs or are unsure, it's best to ask a licensed plumber for a recommendation specific to your plumbing system.