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No, poison isn’t the best way to deal with animals in your attic. It’s unlikely to completely eradicate the problem, especially if you don’t take care of access points. Also, poisoned animals may die and decay in the attic, causing noxious odors. 

Some animals may leave the attic before the poison kills them, which could lead to nearby pets or other wildlife eating the animals and becoming poisoned themselves. Ultimately, it’s better to avoid using poison and contact a professional instead.

While many pests like rats, mice, ants, cockroaches, silverfish, and bed bugs can damage your home, termites are among the most destructive. By sheer dollar amount, the damage from a bad termite infestation is unparalleled, as they can ruin walls, floors, roofs, and wooden support materials, potentially requiring massive reconstruction. Other highly destructive pests include rodents, carpenter ants, and bees that build hives within walls. If you spot signs of termites or other pests, you should hire an exterminator immediately.

The time it takes for termites to damage a house varies, but it generally does not happen within days or weeks. Significant structural damage typically takes several months or years to occur, with serious damage often taking 3 to 8 years. The rate of destruction depends on factors like the termite colony's size and maturity, the type of wood they are feeding on, and local conditions. It can take 3 to 5 years for damage to become visible and 5 to 6 years for the home's structural integrity to be compromised. However, some species, such as Subterranean termites, are more destructive and can cause extensive damage in as little as 2 years. Because of this risk, it is important to treat your home as soon as you notice any signs of termites.

There is no exact science here, due to the nature of nests and how mice raise their young, but a good place to start is to inspect the droppings. A single mouse poops a lot, leaving around 50 droppings in a single day, likely near a primary food source. If you find only sporadic droppings, you likely have a small infestation. If you spot large mounds of droppings, you are dealing with a big problem.