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Smaller is better when patching holes with spackle. Any holes wider than four to six inches in diameter tend to be too wide to repair with spackle alone. You'll likely want to patch bigger holes with a drywall panel. 

Even holes measuring up to 6 inches may be challenging to fill with spackle alone. For best results, purchase a wall repair patch made from wire mesh. Cut the patch to fit over the hole, then use the spackle to hold it in place. Apply the spackle over the patch as you would for a smaller hole.

Technically speaking, you can use drywall primer over plasters. However, oil-based primers work the most effectively on wall plasters. Meanwhile, water-based primers work just as well with drywalls. Nowadays, there are also universal primers suitable for drywall and plaster. Overall, you will be fine as long as you are using a trustworthy brand.

You can put certain types of plaster over other types, but doing so isn't always the best idea. For example, putting a coat of gypsum over lime plaster is possible, but doing so will limit the lime plaster's breathability and potentially affect its performance.

Since cement plaster tends to leave a textured surface, no matter how much you smooth it, some people prefer to use gypsum plaster as a topcoat over cement plaster, creating a smoother surface.

While it’s most common to sand plaster dry, it is possible to wet-sand plaster, too. Doing so can reduce the amount of plaster dust released into the air and make it easier to work in smaller, more delicate areas (such as around wall trim). However, some people find that wet sanding leads to more imperfections, which is why larger walls are more often dry sanded to ensure an even finish.