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It’s very rare to find mice in a bed frame or mattress outside of the most extreme infestation scenarios. That said, your bedroom isn’t off limits for mice if it offers them shelter, food, and warmth. Look for any gaps or openings a mouse could squeeze into, and don’t keep food in your bedroom. 

Finding mouse droppings without seeing any mice is a common sign of an infestation because mice are nocturnal and skilled at hiding from humans. Droppings are often the first and most visible evidence of their presence. The location, quantity, and freshness of the droppings can help you determine where the mice are most active and how severe the infestation might be. Since mice are active at night and often travel through hidden pathways like inside walls, you may not see them directly. It's important to look for other signs of an infestation, such as gnaw marks, scratching sounds, or greasy trails along walls. If you find droppings, consider setting traps or contacting a professional exterminator to address the issue.

Both spikes and loose nets can be installed over nest sites to prevent the bird from returning, but nets are not a humane option since birds and other wildlife can get tangled in them. 

Spikes are a humane alternative that deter nesting without harming the birds. In small areas, like vents, a very fine mesh net can be installed to prevent the bird from returning. These nets don't generally pose a risk to the birds.

Signs include discolored wood, crumbling surfaces, and visible pests. Address these issues promptly to prevent further damage.