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Legal considerations include adherence to local and federal wildlife protection laws, particularly for species that might be protected or endangered.

It’s debatable, but most will say either termites or bed bugs are the hardest to remove. When dealing with termites, you must find the central nest (as opposed to satellite nests) and exterminate the queen and all potential queens, which often takes the work of a specialist. Bed bugs, meanwhile, are incredibly hardy, good at hiding, and resistant to pesticides, so it takes very careful, very thorough work to get rid of them permanently. 

No, poison isn’t the best way to deal with animals in your attic. It’s unlikely to completely eradicate the problem, especially if you don’t take care of access points. Also, poisoned animals may die and decay in the attic, causing noxious odors. 

Some animals may leave the attic before the poison kills them, which could lead to nearby pets or other wildlife eating the animals and becoming poisoned themselves. Ultimately, it’s better to avoid using poison and contact a professional instead.

You can find anti-rat sprays in most home department stores that may be worth a try. Spray them along fences and in areas where you don’t want rats to go (like around decks) and they may think twice before approaching. For a natural version, you can try a mint spray, since rats generally dislike mint. But even the most effective sprays are unlikely to stop a hungry rat over time.