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Mice are very unlikely to go away on their own. As long as there is food and shelter available in your home, they’ll call it their home, too. If your DIY efforts aren’t working, you need to hire a local pest control service to remove the mice infestation. Aside from carrying diseases, mice can chew through wires, insulation, drywall, and more.

According to the Centers for Disease Control and Prevention (CDC), fleas can carry human disease-causing pathogens for Plague, Flea-borne typhus, and Cat scratch disease. These diseases are caused by fleas such as Oropsylla montana, Xenopsylla cheopis, and Ctenocephalides felis, and are commonly found in rural areas of the western United States, California, Texas, and Hawaii. Fleaborne parasites like tapeworms can also be spread to people and animals if they accidentally swallow an infected flea, and small children are at a higher risk. Symptoms may not be present in most infected people.

Poison will kill small rodents and can seem like the quick and easy way to get rid of them. But—in addition to its inhumane nature—poison has some drawbacks. First of all, if you have small children or pets in the home, setting out poison isn't the best idea, as your pets or children could ingest it. 

Poisoned mice and rodents don't die instantly. Instead, it can take several days for the poison to work its way through their system. In the meantime, there's a chance that a predator, such as a cat, fox, or other mammal, will eat the poisoned rodent and become poisoned themselves.

In some cases, a clean house can have roaches, especially if you have excess moisture somewhere. You may want to check for leaky pipes or look underneath sinks to make sure water isn’t dripping near a hidden area that is inviting the cockroaches in. Roaches can also take up residence in clean homes with not-protected food sources, like open bags of food in a kitchen cupboard.