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Squirrels hate not having access to secure shelter or food sources. Your best line of defense is to make your property less attractive by removing access to these things. There are chemical squirrel repellents, but these have mixed success. According to Pennsylvania State University, you can apply products containing the bittering agent denatonium saccharide to a squirrel's favorite fence, tree, or roof spots. However, you need to reapply repellents regularly, which aren’t scientifically proven effective.

Vinegar can keep some animals at bay, like deer, rabbits, foxes, and raccoons. Keep in mind that your household pets, like cats and dogs, also don’t like the smell of vinegar. You can soak rags in white vinegar and put them up around your garden beds to keep the pesky critters from eating your plants.

In addition to a clean home, fleas dislike oils made from plants that are naturally bug-resistant or poisonous to bugs. That includes myrtle, mint, eucalyptus, and especially cedar oil. Common household remedies like baking soda, garlic and apple vinegar don’t have any effect on fleas. Don’t spray essential oils directly on your own skin or your pets (and their bedding, because it can be a skin irritant. Stay away from tea tree oil. In pure form it can be very toxic to pets. Always ask your vet if you have any questions.

You should never use toxic baits or poisons, such as rodenticides designed for mice and rats, to kill or trap possums. Using these toxicants is illegal in many areas and can lead to fines or other penalties. Furthermore, these poisons can cause unnecessary suffering for the animal and pose a significant risk of accidental poisoning to pets or other neighborhood wildlife. Instead of using poisons, it is best to stick with humane methods like live trapping.