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Alongside selecting the best bait for an iguana trap, the location, position, and timing play a part. If the lizards have a burrow in your yard or regularly take the same route, place the trap there during the day. Iguanas are diurnal and most active during the day. A shady spot is best to keep the animal comfortable. And don’t forget to pick a level surface or stabilize the trap with a brick—iguanas are less likely to enter if it’s wobbly.

Squirrels hate not having access to secure shelter or food sources. Your best line of defense is to make your property less attractive by removing access to these things. There are chemical squirrel repellents, but these have mixed success. According to Pennsylvania State University, you can apply products containing the bittering agent denatonium saccharide to a squirrel's favorite fence, tree, or roof spots. However, you need to reapply repellents regularly, which aren’t scientifically proven effective.

While possums don’t typically carry rabies, they can have lice, fleas, ticks, and mites. According to the University of California’s Pest Management Program, possums can also carry diseases like leptospirosis, tuberculosis, toxoplasmosis, coccidiosis, and fevers. Possums are also the carriers of a parasite that can pass to horses and cats called Equine Protozoal Myeloencephalitis (EPM).

Once the animals and their young are out of the house, remove the nest and locate any entry points. Some may be difficult to find because some animals can fit through very small holes. Once you’ve located as many entry points as possible, use materials such as metal or masonry to block off the entry. Ideally, you should choose materials that most animals cannot chew through. Create a one-way door or flap to allow animals to leave but not return. Additional methods include using repellants designed to make an area unappealing to the types of animals that find your home so inviting.