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Poison will kill small rodents and can seem like the quick and easy way to get rid of them. But—in addition to its inhumane nature—poison has some drawbacks. First of all, if you have small children or pets in the home, setting out poison isn't the best idea, as your pets or children could ingest it. 

Poisoned mice and rodents don't die instantly. Instead, it can take several days for the poison to work its way through their system. In the meantime, there's a chance that a predator, such as a cat, fox, or other mammal, will eat the poisoned rodent and become poisoned themselves.

While keeping any critter away permanently isn’t always possible, you can keep mice away from your home by setting traps, fumigating your space, and sealing known entry points. Once you’ve taken these steps, take time to work on prevention measures, such as clearing out all clutter and recyclables and removing all food sources.

A solution of vinegar and water can deter moles, but be careful about the strength of the solution. Too much vinegar can dry out and kill grass or other plants when distributed too frequently.

It is highly unlikely that fleas will go away on their own without treatment. Female fleas can lay dozens of eggs per day—up to 50—causing their numbers to multiply quickly and spread throughout your home. An adult flea can live for around 100 days or even up to a year as long as it has access to a host, such as a pet or human. Even without a host to feed on, fleas can survive for weeks. Because of their rapid reproduction and resilience, it's best to tackle a flea problem as soon as possible. Hiring an exterminator is recommended to prevent the infestation from worsening.