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This varies based on the circumstance. Chemical-based pest control baits and poisons are usually the most potent, but they are unsafe to use around children and pets, so they won’t be a fit for every household.

Safer alternatives, such as boric acid and food-grade diatomaceous earth, can work as well, though they should still stay out of reach. Aside from that, the best thing any DIY-er can do is make their place uninviting by sealing off entry points, eliminating clutter, and maintaining a clean home.

Always begin by removing the gnat's source of food. Toss rotting fruit, place new fruit in the fridge, and switch the soil of your houseplants. 

The best way to get rid of gnats in the kitchen is by baiting and trapping them with something sweet. Combine water with a few drops of dish soap, apple cider vinegar, and 1 tablespoon of sugar into a bowl. Cover with plastic wrap and poke small holes to trap the gnat in the liquid.

Set live traps or install a one-way door to evict squirrels, rodents, and other animals from your attic. Once they’re out, seal any entry points to prevent the animals from returning. If you’re dealing with an infestation, call a pro. 

Fruit flies are more common during warm-weather months and may go away on their own in late fall once temperatures drop. However, they can survive year-round indoors as long as there's food available, so you'll likely want to take a proactive approach to get rid of them and stop the spread of bacteria.