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No, poison isn’t the best way to deal with animals in your attic. It’s unlikely to completely eradicate the problem, especially if you don’t take care of access points. Also, poisoned animals may die and decay in the attic, causing noxious odors. 

Some animals may leave the attic before the poison kills them, which could lead to nearby pets or other wildlife eating the animals and becoming poisoned themselves. Ultimately, it’s better to avoid using poison and contact a professional instead.

The best deterrents for possums include securing trash cans with tight-fitting lids, removing outdoor food sources like pet food or fallen fruit, and trimming tree branches that provide access to your roof or an open window. Motion-activated lights or sprinklers can also startle and discourage them from visiting. Additionally, you can take advantage of their strong sense of smell by using garlic, onion, or commercial possum repellents to keep them off your property.

You’ll find groundhogs are most active during the morning hours and late afternoon, but they want to avoid humans at all costs. If you do set a trap, you can set it out the night before so it’s waiting on them the next morning, and try to remove any human scent when setting it out.

Scented mouse deterrents, like peppermint oil, can be effective in the short term. The pungent smells may temporarily repel mice, but they lose effectiveness as the scent fades or mice get used to it. The main drawbacks are frequent reapplication and the fact that these deterrents don't address the root cause of the infestation, such as entry points or food sources. While they can be part of a broader strategy, scented deterrents alone are rarely enough to eliminate a mouse problem.