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Although they are used for similar tasks, spackle and joint compound are not the same. Joint compound, also known as drywall mud, consists of limestone and gypsum and is primarily used for large-scale projects like taping and finishing seams on new drywall. Spackle is composed of gypsum and binding agents, making it a thicker compound best suited for small wall repairs like filling nail holes or cracks, as it dries quickly and is easy to sand. For small repairs, either product can be suitable. However, you can use joint compound for small jobs in place of spackle, but you cannot use spackle for large-scale taping and mudding projects.

Drywall can be toxic to the environment and to humans in some cases. As drywall breaks down in a landfill and comes in contact with other organic chemicals, it can create hydrogen sulfide gas or leach into the groundwater. Additionally, the CDC recommends methods for controlling the inhalation of drywall dust when handled. While the common ingredients of drywall—gypsum, silica, and mica—are naturally occurring, they can cause irritation in some humans.

Whether you need drywall anchors depends on your specific project, particularly where you are hanging an item. Drywall anchors are not necessary if you can drive a screw directly into a wooden stud behind the wall, as the stud provides sufficient support. However, since studs are not present everywhere in a wall, you will need to use drywall anchors if you are hanging an object in a location without a stud. For very lightweight items, picture hanging strips can also be a suitable alternative.

You should not leave drywall outside, especially overnight or in a wet, humid climate. Exposure to rain and humidity can damage the drywall, weakening its structural integrity and making it susceptible to mold growth. If you must leave drywall outside during a project, be sure to cover it with a tarp or keep it inside a storage shed to protect it. Even drywall intended for exterior projects requires a protective moisture barrier. For best results, store any extra drywall in a dry area away from the elements.