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Most commercial liquid drain cleaners work in 15 to 30 minutes. Consult the label on the bottle for additional instructions or time suggestions to prevent damage to your drainpipes. Alternative solutions such as baking soda, salt, white vinegar, and/or boiling water can take longer since they are less harsh than liquid drain cleaners.

There are many things that could cause your basement floor drain to back up. One significant cause of a drainage backup is flushing non-flushable items, such as wipes, paper towels, and facial tissue. Other causes of a backed-up basement floor drain include tree roots impeding the drain pipe or an accumulation of hair, oil, and grease. 

If you leave liquid drain cleaner for too long, it will start breaking down your drainpipes. The chemicals in these cleaners can cause cracks, corrosion, and leaks in your pipes. They can also damage plumbing fixtures and even cause environmental damage if left too long without rinsing away.

Some flushable wipes companies say they are designed to disintegrate within a few hours to a few days after being flushed. These wipes allegedly use materials that are more water-soluble than traditional wipes. However, many experts have raised concerns that even so-called "flushable" wipes do not break down as easily as claimed and can contribute to clogs and blockages in sewer systems.

To prevent plumbing and sewer problems, avoid flushing wipes, even those labeled as flushable. Instead, dispose of them in the trash. This can help prevent costly plumbing issues and reduce the strain on wastewater treatment systems.