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You should never use toxic baits or poisons, such as rodenticides designed for mice and rats, to kill or trap possums. Using these toxicants is illegal in many areas and can lead to fines or other penalties. Furthermore, these poisons can cause unnecessary suffering for the animal and pose a significant risk of accidental poisoning to pets or other neighborhood wildlife. Instead of using poisons, it is best to stick with humane methods like live trapping.

It’s possible that skunks will leave on their own. Skunks may appear briefly on your property and move on if they cannot find food. However, waiting them out is not a foolproof solution. If the skunk finds a food source on or near your property and builds a nest, the animal will almost certainly not choose to move. If you can eliminate food sources, you’ll have a better chance of seeing the skunk leave on its own.

Squirrels hate not having access to secure shelter or food sources. Your best line of defense is to make your property less attractive by removing access to these things. There are chemical squirrel repellents, but these have mixed success. According to Pennsylvania State University, you can apply products containing the bittering agent denatonium saccharide to a squirrel's favorite fence, tree, or roof spots. However, you need to reapply repellents regularly, which aren’t scientifically proven effective.

Setting up an animal trap in your yard largely depends on where you live and the type of critter you're dealing with. In many states, trapping nuisance animals like squirrels, rats, or raccoons is allowed, sometimes without needing a permit. However, certain wildlife species are protected, and not all states have lenient catch-and-release regulations.

Before placing a trap, check your local laws to avoid fines or other legal issues. Some areas allow DIY trapping, while others may require professional assistance. Most areas require a professional to relocate the animal once trapped. Consulting a pro ensures you handle the situation responsibly, humanely, and within the law.