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No, poison isn’t the best way to deal with animals in your attic. It’s unlikely to completely eradicate the problem, especially if you don’t take care of access points. Also, poisoned animals may die and decay in the attic, causing noxious odors. 

Some animals may leave the attic before the poison kills them, which could lead to nearby pets or other wildlife eating the animals and becoming poisoned themselves. Ultimately, it’s better to avoid using poison and contact a professional instead.

Squirrels tend to forage, traveling along roof and fence lines. To trap a squirrel, placing a baited trap on the roof near the point of entry is the best option. If you can see them going in and out or recognize the damage they might be causing to the exterior of your home, you can also try placing traps near those locations.

Numerous predators kill hornets, including frogs, birds, lizards, bats, spiders, and hedgehogs. Some larger predators, including rats, skunks, and racoons, will occasionally attack a hornet nest in order to eat the larvae inside. These natural predators typically don’t eat enough hornets to make them an effective form of hornet control. 

It’s very rare to find mice in a bed frame or mattress outside of the most extreme infestation scenarios. That said, your bedroom isn’t off limits for mice if it offers them shelter, food, and warmth. Look for any gaps or openings a mouse could squeeze into, and don’t keep food in your bedroom.