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You may find fleas in your bed if they followed you there on your pet or your clothing. While they will need you or an animal as a host, they can hide in bedding since it is warm and out of sight. If you spot signs of fleas or see live fleas in your bed, hire a flea control specialist immediately to eradicate the infestation and prevent it from spreading further.

You can use a homemade spray to kill fleas on a mattress. To make the spray, combine equal parts water and distilled white vinegar. Spray the mixture on the fleas and all over the mattress. Follow this up with a generous sprinkle of salt all over the mattress, and let it sit overnight. Finally, vacuum the mattress to clean up the salt, dead fleas, and flea offspring.

Spiders are not typically attracted to bedding as a primary source of food or shelter, but they sometimes inadvertently end up there. Spiders can hitch a ride on your clothing, belongings, or through open windows and doors. The underside of a bed, especially if it's near a wall or corner, can provide such a sheltered spot where they can hide and build webs. Dust and clutter under your bed can create ideal hiding places as well. If your room has other insects like flies or mosquitoes, spiders may be drawn to the area in search of prey. 

DIY animal removal is rarely a good idea and is not advised for many reasons. First, these types of animals can carry diseases and, therefore, pose a health risk to you, your family, and your pets if mishandled. Second, depending on your city or municipality, it may be illegal to remove or handle wildlife yourself. 

Sealing your home against these animals yourself is also a bad idea. Trapping an animal under your house will cause odor and insect problems when it passes away.