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You can use baking soda to start getting the urine odor out of your mattress. Baking soda is highly absorbent and soaks up odors, so it will not only draw the urine out of your mattress but it can also get to work fighting the lingering smell. You can also use an enzymatic cleaner to break down the urine to make it easier to clean. Just keep in mind that you need to remove enzymatic cleaners from the mattress after use, as leaving them on could be dangerous.

To maintain your mattress and keep it fresh, you should aim for a deep clean at least twice a year. However, if you have allergies, pets, or sweat heavily at night, you may want to clean it more frequently, such as every three to four months. In between deep cleanings, it's a good practice to vacuum the mattress surface regularly and spot-clean any stains as they occur. Using a mattress protector can significantly help by minimizing the buildup of allergens, dust mites, and bodily fluids, which can make your cleaning routine more effective. Remember to launder the protector regularly, as some dirt and sweat can still get through to the mattress.

Most people perform the bulk of their household cleaning tasks once a week. Since a whole-home, top-to-bottom weekly cleaning can take up a significant chunk of time, break weekly tasks up by day so you don’t have to lose your whole weekend to cleaning and maintaining your house. Many people also find the cost of a house cleaner to be worth it to help keep their home clean if it’s hard to find the time themselves.

Smoke stains, grease buildup, mold, and water spots are common reasons for hiring professional cleaning services.