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Buffalo grass is not a dense grass, so weeds can grow between the buffalo grass plants. However, as long as you don’t overwater your lawn, weeds have a hard time growing. If you do notice weeds, you can use granular herbicides that are safe for buffalo grass in early and late summer.

No, it's not really possible to completely prevent weed growth. Weeds are incredibly resilient—all they usually need is a tiny bit of dirt to sprout, so their eventual appearance is pretty much inevitable. However, you can definitely keep them at bay by getting rid of weeds as soon as you notice them. The longer you let them sit and grow roots, the more they'll spread.

A spot herbicide for weed control is effective at killing crabgrass and not grass, but it depends on the type of herbicide. Always check the label to ensure that your herbicide is safe for grass but tough on crabgrass. Overall, spot treatment is ideal because it puts fewer herbicides into the soil, which can damage the soil. If you’re wanting a natural remedy to crabgrass that also won’t harm surrounding grass, you can also hand-remove crabgrass or even pour boiling water or 5% vinegar over crabgrass as a spot treatment.

The most effective way to eliminate quack grass without killing the grass nearby is to overseed the area, keep the seed wet until it grows, mow often, and regularly fertilize the area to promote healthy grass that can choke out the invasive weed.