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While possums don’t typically carry rabies, they can have lice, fleas, ticks, and mites. According to the University of California’s Pest Management Program, possums can also carry diseases like leptospirosis, tuberculosis, toxoplasmosis, coccidiosis, and fevers. Possums are also the carriers of a parasite that can pass to horses and cats called Equine Protozoal Myeloencephalitis (EPM).

If the cat is stray (you noticed a collar or other signs of domestication), the kind thing to do is to try and find the owner. Call around to other neighbors to see if they can lead you in the right direction. If you can get close enough to snap a picture, try posting an image of the cat to local community groups and pages on social media. 

If the cat is feral, you can try to humanely trap them and participate in a local shelter’s TNR program. Before attempting capture, call around to local rescues and shelters to make sure one near you does participate in a TNR program. They may even be able to catch the cat for you.

Besides reptile sightings, look for droppings resembling small pellets. Shed skin left behind during growth is another clue. Unusual chirping or rustling sounds could also suggest an infestation. If unsure, consulting a professional can provide accurate identification and effective solutions for managing the situation. If proper pest prevention measures aren't taken, a lizard can live up to five years. And that's a long time to have an undesirable roommate.

This varies based on the circumstance. Chemical-based pest control baits and poisons are usually the most potent, but they are unsafe to use around children and pets, so they won’t be a fit for every household.

Safer alternatives, such as boric acid and food-grade diatomaceous earth, can work as well, though they should still stay out of reach. Aside from that, the best thing any DIY-er can do is make their place uninviting by sealing off entry points, eliminating clutter, and maintaining a clean home.