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Although they have similar applications, spackle and joint compound are not the same. Their primary differences lie in their composition, consistency, and ideal use cases.

Spackle is composed of gypsum and binding agents, making it thicker than joint compound. It dries quickly and is easy to sand, which makes it ideal for small wall repair projects like filling nail holes or patching minor damage.

Joint compound, also known as drywall mud, consists of limestone and gypsum. It is primarily used for large-scale projects, such as taping and finishing the seams on newly installed drywall. It tends to shrink more than spackle and can be more difficult to spread.

While both products can be used to fill small depressions and cracks, spackle cannot replace joint compound for taping and mudding new drywall. Conversely, you can often use joint compound for small patching jobs typically done with spackle.

Drywall is safe to cut as long as you follow proper procedures, such as wearing personal protective equipment and using the right tools to score and cut the drywall. When cutting new drywall, it can release dust with silica and other compounds that could pose health risks. Leave cutting drywall to the pros, or wear a high-quality respiratory mask, goggles, and other PPE when handling drywall.

You’ll get better results if you soundproof the whole wall. A hole through which light can pass can also let sound waves in. Acoustical or silicone sealant applied to holes and cracks can block enough sound to make a difference. However, the more layers absorb vibrations and slow or stop sound waves, the less noise you’ll have. 

While not always necessary, you can glue a drywall ceiling in addition to using screws or nails. Drywall is typically secured to ceiling joists with fasteners, which is often sufficient. However, adding construction adhesive can offer benefits like preventing sagging, bridging gaps, and reducing air leaks for better energy efficiency. It may also be used for specific acoustic or insulation needs. On the other hand, many professionals advise against it because properly placed screws make the drywall structural, glue doesn't add strength, and it makes future repairs or replacements significantly more difficult. Ultimately, it's best to follow local building codes and project-specific requirements to decide if adhesive is right for your ceiling.