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No, it's not really possible to completely prevent weed growth. Weeds are incredibly resilient—all they usually need is a tiny bit of dirt to sprout, so their eventual appearance is pretty much inevitable. However, you can definitely keep them at bay by getting rid of weeds as soon as you notice them. The longer you let them sit and grow roots, the more they'll spread.

Yellow leaves and stems on your sprouts indicate they’re not getting enough light. Keep them near the appropriate light source and give them as much as they need (they require longer exposure to fluorescence than they do to natural light sources).

If you have a lot of tree roots in your yard or have experienced issues in the past, you should use tree root killer every six months to prevent roots from infiltrating your pipes. If you have an active invasion and aren’t seeing results, check the instructions on the bottle to see how often you can use it in a short period of mine.

Landscaping fabric can only help to prevent weed growth in the short term. It's not an ideal long-term solution because dirt will eventually make its way on top of it, causing weeds to sprout. These fabrics can also leave microplastics in the environment for many, many years, so pulling weeds using one of the methods in this guide as soon as you see them is a better long-term prevention strategy.