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An active cleaning agent and a drain snake is the best way to clean a main sewer line. You can purchase a regular or enzyme drain cleaner or make a DIY drain cleaner with baking soda. Use your chosen solution at least once a month or as needed to keep your sewer line clear. 

There are several common signs that your main sewer line may be clogged. Key indicators include multiple fixtures in your home draining slowly, gurgling sounds coming from drains or toilets, and water backing up into showers, sinks, or toilets. You might also notice water backing up from the plumbing system's drain cleanout, water in your basement drain, or unexplained wet patches on your lawn. Foul odors, such as the smell of raw sewage or rotten eggs, are another common symptom. The most reliable way to confirm a main sewer line clog is to hire a professional plumber to perform a camera inspection.

If used correctly and sparingly, root killer shouldn’t damage your pipes. Make sure to follow the instructions on the back of the bottle or the company’s website to avoid any unintended damages. However, when it comes to copper sulfate, it’s better to avoid it. This type of root killer can damage your plumbing and the surrounding environment.

There is conflicting advice on whether to leave a baking soda and vinegar mixture in a drain overnight. Some sources suggest it can be effective for tough clogs, recommending that you flush the drain with warm water in the morning as part of a monthly cleaning routine. However, other experts advise against leaving the mixture in for extended periods, as its caustic nature could corrode drainpipes if used too often or left in for too long.