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Possums don’t typically pose a danger to humans—they prefer to stay out of sight. If they feel threatened, they play dead instead of engaging. However, they can become aggressive when cornered, typically when they become trapped inside your home or when a dog chases them. When this happens, it’s best to call a wildlife control service near you to remove possums safely.

Mice are very unlikely to go away on their own. As long as there is food and shelter available in your home, they’ll call it their home, too. If your DIY efforts aren’t working, you need to hire a local pest control service to remove the mice infestation. Aside from carrying diseases, mice can chew through wires, insulation, drywall, and more.

It may be better to have a mouse in your house than a rat. Rats are larger, more aggressive, and more difficult to eradicate once settled. One rat can cause more damage than one mouse. However, both animals pose a danger in that they can spread bacteria and contaminate food, so you’ll want to contact an exterminator as soon as you detect an infestation of either animal.

You should never use toxic baits or poisons, such as rodenticides designed for mice and rats, to kill or trap possums. Using these toxicants is illegal in many areas and can lead to fines or other penalties. Furthermore, these poisons can cause unnecessary suffering for the animal and pose a significant risk of accidental poisoning to pets or other neighborhood wildlife. Instead of using poisons, it is best to stick with humane methods like live trapping.