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It’s debatable, but most will say either termites or bed bugs are the hardest to remove. When dealing with termites, you must find the central nest (as opposed to satellite nests) and exterminate the queen and all potential queens, which often takes the work of a specialist. Bed bugs, meanwhile, are incredibly hardy, good at hiding, and resistant to pesticides, so it takes very careful, very thorough work to get rid of them permanently. 

Roaches won’t sting your pets and don’t have venom like spiders do , but they present other dangers. Cockroaches are notorious carriers of diseases like salmonella and parasites like tapeworms. Because they’re so dirty, their bites (otherwise harmless) can also get infected. You don’t want your pets chasing and trying to eat cockroaches, or sleeping near a roach infestation. 

For years, it was believed that hobo spider bites were incredibly dangerous, causing flesh-eating wounds. But the rumors of their bites were greatly exaggerated, and there's been no real evidence showing a connection between a hobo spider bite and necrotizing wounds. 

That said, the spiders can and do bite, usually as a defense response. They won't attack you unprovoked, but if you take them by surprise and get close enough, they may bite you. Their bites may cause some minor irritation or itchiness. 

The number of spiders considered normal in a house can vary significantly depending on geographic location, season, and the specific environment of the house. Generally, it's common for a home to have one or two spiders present at any time. If you consistently notice more than one spider in your home daily or you're dealing with potentially dangerous species, it's advisable to seek professional pest control services to address the issue.