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While many pests like rats, mice, ants, cockroaches, silverfish, and bed bugs can damage your home, termites are among the most destructive. By sheer dollar amount, the damage from a bad termite infestation is unparalleled, as they can ruin walls, floors, roofs, and wooden support materials, potentially requiring massive reconstruction. Other highly destructive pests include rodents, carpenter ants, and bees that build hives within walls. If you spot signs of termites or other pests, you should hire an exterminator immediately.

Spiders are not typically attracted to bedding as a primary source of food or shelter, but they sometimes inadvertently end up there. Spiders can hitch a ride on your clothing, belongings, or through open windows and doors. The underside of a bed, especially if it's near a wall or corner, can provide such a sheltered spot where they can hide and build webs. Dust and clutter under your bed can create ideal hiding places as well. If your room has other insects like flies or mosquitoes, spiders may be drawn to the area in search of prey. 

The signs of a bed bug infestation include itchy, red bite marks on the skin and various forms of physical evidence on or near your bed. Look for reddish or rust-colored stains on sheets from crushed bed bugs, as well as small, dark fecal droppings. You might also find the bugs themselves, their tiny eggs, or the pale, molted skins (casings) they leave behind. In some cases, a persistent musty odor may be present. If you notice any of these signs, calling a professional exterminator is the most effective way to handle the infestation.

While it may seem counterintuitive, it is best to continue sleeping in your bed even if you have a bed bug infestation. If you move to another room, the bed bugs may follow you, which can spread the infestation to other parts of your home. To minimize bites while you sleep, wear protective clothing that covers as much of your body as possible, such as long-sleeved shirts, long pants, and socks. In the meantime, you should also isolate any potentially infested belongings and take steps to kill the bed bugs on your mattress as quickly as possible while waiting for professional treatment.