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This varies based on the circumstance. Chemical-based pest control baits and poisons are usually the most potent, but they are unsafe to use around children and pets, so they won’t be a fit for every household.

Safer alternatives, such as boric acid and food-grade diatomaceous earth, can work as well, though they should still stay out of reach. Aside from that, the best thing any DIY-er can do is make their place uninviting by sealing off entry points, eliminating clutter, and maintaining a clean home.

Even if you have extreme ophidiophobia (fear of snakes), don’t try to shoot or kill them with a shovel. Besides being pretty cruel, killing snakes in most states is illegal unless your life is at risk and many species are protected. 

Plus, you're putting yourself at greater risk using these techniques if it goes wrong and the now-angry snake is venomous.

Seeing a rat or two isn’t uncommon, especially in mild climates. That doesn’t mean they are actively a danger to your home. The problem is when you start seeing rats regularly in your yard, there’s a good chance they are also looking for ways to get into your house or other buildings. All they need is a small hole or gap, and they have a new place to nest -- which is bad news for you. Stay cautious if you start seeing rats in your yard all the time. 

Finding mouse droppings without seeing any mice is a common sign of an infestation because mice are nocturnal and skilled at hiding from humans. Droppings are often the first and most visible evidence of their presence. The location, quantity, and freshness of the droppings can help you determine where the mice are most active and how severe the infestation might be. Since mice are active at night and often travel through hidden pathways like inside walls, you may not see them directly. It's important to look for other signs of an infestation, such as gnaw marks, scratching sounds, or greasy trails along walls. If you find droppings, consider setting traps or contacting a professional exterminator to address the issue.