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Vinegar cannot tell the difference between weeds and desired grass types; it kills everything it touches. Only use a vinegar or vinegar-based solution if you are relatively confident that you can navigate around the plants and grasses you want to keep. Also, don’t spray vinegar on a windy day, or it will blow onto other plants.

Glyphosate and other non-selective herbicides can kill orchard grass, but they will also kill the surrounding plants. Also, not all areas allow the use of glyphosate due to its environmental impact—which the EPA describes as a "potential risk to terrestrial and aquatic plants and birds, and low toxicity to honeybees." Consider mechanical removal to target the plants specifically.

Mowing a lawn will, unfortunately, not get rid of clover, and it may even encourage it to flourish. Let your lawn grow to a healthy height of over 3 inches and then set your mower blades no lower than this level. Higher grass will cut out the light that clover loves and discourage it from spreading.

If you spray a DIY vinegar solution that contains high salt, it can disrupt the soil's structure and make it difficult for plants to grow. That's why it's vital to avoid spraying vinegar solution on areas where you are trying to grow plants and flowers. When using a mix of vinegar and soap, some say you can plant a few days after the vinegar dries.