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Glyphosate and other non-selective herbicides can kill orchard grass, but they will also kill the surrounding plants. Also, not all areas allow the use of glyphosate due to its environmental impact—which the EPA describes as a "potential risk to terrestrial and aquatic plants and birds, and low toxicity to honeybees." Consider mechanical removal to target the plants specifically.

You should add 1 to 4 inches of mulch, depending on your garden type and needs. Keep in mind that no amount of mulch can completely prevent weeds, but a heavier coverage (closer to 4 inches) can suppress weeds enough that you are only seeing them sprout every few weeks. Finer mulch prevents weeds more effectively than large mulch, so if you’re using mulched leaves or shredded bark, 1 to 2 inches will likely suffice, while 3 to 4 inches is best for larger mulch, like bark chips or straw.

It’s not legal to intentionally damage a neighbor’s tree. Even if the roots of a tree encroach into your yard, if you damage or kill a tree that belongs to your neighbor, you can be held liable for the damage in most cases. Since herbicides can spread through the tree, causing damage to the whole tree and not just the roots that are on your side of the property line, you shouldn’t poison your neighbor’s tree. The other downside to this method is that if the tree dies, it can fall onto your property and cause more damage, so herbicides are best avoided in this circumstance.

Ultimately, pulling weeds vs. spraying them depends on what’s happening in your yard and your personal preferences. Manual weed removal doesn’t introduce any chemicals into your landscape, targets specific problematic plants, produces immediate results, can be free if you go the DIY route, and is inexpensive with a weed service if you only have a handful of weeds. On the other hand, spraying is often preferable for severe weed infestations and situations involving difficult-to-pull weeds because it treats multiple weeds at once, is usually more effective long-term, is less time-consuming, and costs less when done by a pro.