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It is very difficult to remove a colony entirely without using some kind of insecticide. However, some treatments are safer than others. Diatomaceous earth is a non-toxic powder application that creates barriers that insects can’t pass through. Some pest control companies offer liquid nitrogen treatments to freeze out termites without using pesticides. Some chemical treatments are safer to use around plants, water, and wildlife than others. Bait stations are generally less damaging to the environment than sprayed termiticides.

Roof rats can carry a variety of pathogens and parasites, including salmonellosis (food contamination), leptospirosis, trichinosis, rat-bite fever, murine typhus, plague, and toxoplasmosis. Diseases can be spread via urine, droppings, or saliva. To prevent transmission, it’s essential to promptly address a roof rat infestation and avoid direct contact with the animals where possible.

A solution of one part bleach to 10 parts water or a disinfecting product that contains phenol (such as Lysol) is known to kill hantavirus and other pathogens found in mouse urine and feces. Simply spray this solution over and around the locations you expect mice to be living and running through, and the homemade disinfectant will do its job to rid your home of any feces and urine particles you could be exposed to.

While keeping any critter away permanently isn’t always possible, you can keep mice away from your home by setting traps, fumigating your space, and sealing known entry points. Once you’ve taken these steps, take time to work on prevention measures, such as clearing out all clutter and recyclables and removing all food sources.