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In framing, studs are placed at 16-inch intervals to coincide with the typical spacing of wall materials such as drywall or plywood. This spacing is called "on-center" and is necessary for maintaining structural stability and efficient use of materials. The 16-inch spacing also helps to distribute the weight evenly across the building's structure. For those looking to cut material costs and improve energy efficiency, 24-inch stud spacing can be employed through a method called "advanced framing". This requires careful planning and adherence to local building codes to ensure structural integrity.

Drywall can be toxic to the environment and to humans in some cases. As drywall breaks down in a landfill and comes in contact with other organic chemicals, it can create hydrogen sulfide gas or leach into the groundwater. Additionally, the CDC recommends methods for controlling the inhalation of drywall dust when handled. While the common ingredients of drywall—gypsum, silica, and mica—are naturally occurring, they can cause irritation in some humans.

Yes, it matters which side of drywall you use. One side is smooth, and the other is rough. The smooth side should be facing outward, toward the room, while the rough side should be hidden and facing the studs and framing of the house. The smooth side will be easier to apply tape, joint compound, and, later, paint to.

Whether you need a drywall anchor depends on the specifics of your project, particularly what you're hanging and where. You do not need a drywall anchor if you can screw or nail the object directly into a wooden stud, as the wood provides sufficient support and stability. However, if there are no studs in the location where you plan to hang the item, you should use drywall anchors to ensure it is securely supported. For very lightweight objects, like small pictures, adhesive picture hanging strips can be a suitable alternative to anchors.