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Buffalo grass is not a dense grass, so weeds can grow between the buffalo grass plants. However, as long as you don’t overwater your lawn, weeds have a hard time growing. If you do notice weeds, you can use granular herbicides that are safe for buffalo grass in early and late summer.

The safest method to avoid killing your turf grass is hand pulling Johnsongrass. You can also apply vinegar for a safer herbicide, but it will still burn your lawn if it gets on it.

Purchase a selective herbicide that targets clover and similar weeds but doesn't take out your grass. You can also keep it from growing with corn meal gluten or remove clover from your lawn manually at the start of the season as part of your lawn maintenance checklist.

Glyphosate and other non-selective herbicides can kill orchard grass, but they will also kill the surrounding plants. Also, not all areas allow the use of glyphosate due to its environmental impact—which the EPA describes as a "potential risk to terrestrial and aquatic plants and birds, and low toxicity to honeybees." Consider mechanical removal to target the plants specifically.