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Yes, Johnsongrass is a hard weed to kill. It has the ability to grow fast and spread even quicker, so it requires a detailed plan and thorough application to eliminate it. The best plan of action is to kill Johnsongrass while the weed is establishing itself by hiring a lawn care professional or following the steps above. 

Glyphosate and other non-selective herbicides can kill orchard grass, but they will also kill the surrounding plants. Also, not all areas allow the use of glyphosate due to its environmental impact—which the EPA describes as a "potential risk to terrestrial and aquatic plants and birds, and low toxicity to honeybees." Consider mechanical removal to target the plants specifically.

Vinegar is known to be a contact herbicide, which means it kills the foliage it comes in contact with. Because of the high acetic acid concentration, horticultural vinegar kills weeds and grass more effectively. However, keep in mind that high amounts and multiple applications can affect the soil by lowering the pH levels.

It usually takes between two weeks and a month for weeds to fully die off after you spray them with herbicide, but they will start to wilt within the first week. Different weed sprays produce different results, with some working more quickly and effectively than others. Similarly, some weeds are killed more easily than others. Consult your weed removal pro for an exact timeline based on their weed removal method.