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Do not mix bleach with vinegar, ammonia, acidic liquids, or other cleaners or detergents as toxic fumes result from the chemical reaction. Mix bleach only with water to avoid dangerous chemical reactions. Even mixed with water to dilute it, bleach can still be harmful to your skin, eyes, and lungs.

The formula for neutralizing skunk smell is one quart of 3% hydrogen peroxide, ¼ cup baking soda, and one to two teaspoons of dish soap. The University of Nebraska says a chemist discovered that this mixture changes the thiols, the chemical compound that causes the odor, into acids that don’t carry a skunk smell, thus eliminating the odor.

A mild skunk smell in your house can last up to three weeks, dissipating over time with proper ventilation. However, if you leave stronger smells untreated, they can last for months or years, becoming more difficult to remove the longer they sit. This is especially true of odors that have seeped into fabrics such as clothing or furniture or those in your pets’ fur.

It is worth it to clean a mattress regularly for several reasons. For one, you'll increase the usable life span of the mattress, saving you from buying new mattresses as frequently. You'll also improve your home's indoor air quality and reduce odors and bacteria, both of which can positively impact the health of your household.