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This varies based on the circumstance. Chemical-based pest control baits and poisons are usually the most potent, but they are unsafe to use around children and pets, so they won’t be a fit for every household.

Safer alternatives, such as boric acid and food-grade diatomaceous earth, can work as well, though they should still stay out of reach. Aside from that, the best thing any DIY-er can do is make their place uninviting by sealing off entry points, eliminating clutter, and maintaining a clean home.

Spiders are not typically attracted to bedding as a primary source of food or shelter, but they sometimes inadvertently end up there. Spiders can hitch a ride on your clothing, belongings, or through open windows and doors. The underside of a bed, especially if it's near a wall or corner, can provide such a sheltered spot where they can hide and build webs. Dust and clutter under your bed can create ideal hiding places as well. If your room has other insects like flies or mosquitoes, spiders may be drawn to the area in search of prey. 

Carpet beetles don’t seek shelter in mattresses like bed bugs do, but there still may be sources of food, like the fabric of your sheets and blankets, that attract carpet beetles. Because these pests munch on plant-based materials, you could still find one in your bed as it’s searching for food.

Brown recluse spiders are found in Midwestern and South Central states like Nebraska, Ohio, Texas, and Georgia. While it’s possible to find spiders from the same genus elsewhere in the country, you’re unlikely to find a brown recluse infestation outside of these designated zones. In any case, there are other dangerous spider species across the U.S., so always use caution when dealing with infestations of any kind.