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For maximum stability, install grab bars on wall studs, as this will adequately support the weight. However, if you don't have access to studs, you can get by with wall anchors. If opting for the latter, choose specialty hollow wall anchors. 

A 50-pound mirror can be hung on drywall, but only if it has the support of strong hardware. Ideally, you can find the studs behind the drywall and attach the mirror to them; this will give your mirror better stability. Otherwise, confirm that you are using anchors appropriate to the weight of the mirrors. Another technique is to use French cleats—two pieces of wood that fit together, with one piece attached to the wall and the other to the mirror. This allows the weight to be distributed over a wider area.

You should always hang drywall from the top down. Starting at the top makes it easier to create a straight, tight line between the ceiling and the wall. Any gaps that occur will be at the bottom, where they are easier to manage. You can either cut the bottom piece of drywall to fit the remaining space or cover the gap with baseboard trim. Additionally, starting at the top is physically easier, as you won't have to fit the top sheet into a tight space between the lower sheet and the ceiling, or try to balance the upper sheets on the lower ones while securing them.

Whether to repair or replace water-damaged plaster depends on the scale of the damage. For small, limited areas, you can often perform a repair yourself. If you choose to paint over small patches, ensure the surface is completely dry and apply a coat of antifungal primer first to prevent mold growth. However, simply painting or plastering over the damage is only a temporary solution that doesn't address the core problem. For more extensive or long-term damage, the plaster may be compromised, and there is a risk of mold. In these cases, it is recommended to remove the damaged section of plasterboard and replace it. You may consider hiring a professional for the repair, and it's worth noting that water damage is often covered by home insurance.