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DIY animal removal is rarely a good idea and is not advised for many reasons. First, these types of animals can carry diseases and, therefore, pose a health risk to you, your family, and your pets if mishandled. Second, depending on your city or municipality, it may be illegal to remove or handle wildlife yourself. 

Sealing your home against these animals yourself is also a bad idea. Trapping an animal under your house will cause odor and insect problems when it passes away. 

If you are not at high risk of contracting disease and take proper safety precautions, it’s considered generally safe to clean mouse droppings on your own. Before handling any droppings, make sure to put on protective equipment such as plastic gloves and a face mask. Individuals who are immunocompromised, have medical conditions, and children should especially avoid exposure to mouse droppings. 

Most spiders are harmless or do little more than the equivalent of a bee sting. Prevention is the best option for more serious cases. Keep spiders out of your home when possible. When you find spiders, a spider nest, or egg sac, remove it quickly before an inquisitive pet or child gets involved. When children are old enough, teach them to recognize the few dangerous species of spiders and avoid them to prevent getting bitten.

Squirrels rely heavily on their sense of smell and are deterred by a variety of scents. Some of the most effective smells for repelling them include peppermint oil, coffee grounds, white vinegar, garlic, cinnamon, rosemary, and predator urine. They also have a strong aversion to capsaicin, the compound that makes chili peppers hot, making capsaicin-based sprays an effective repellent for areas like gardens or bird feeders. For a DIY solution, you can create a spray from garlic and vinegar and apply it daily. Additionally, squirrels dislike strong, fresh scents, so placing items like strong-smelling soaps or dryer sheets in areas they frequent can also help keep them away.