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Buffalo grass is not a dense grass, so weeds can grow between the buffalo grass plants. However, as long as you don’t overwater your lawn, weeds have a hard time growing. If you do notice weeds, you can use granular herbicides that are safe for buffalo grass in early and late summer.

Vinegar cannot tell the difference between weeds and desired grass types; it kills everything it touches. Only use a vinegar or vinegar-based solution if you are relatively confident that you can navigate around the plants and grasses you want to keep. Also, don’t spray vinegar on a windy day, or it will blow onto other plants.

The fastest ways to kill weeds and unwanted grass include burning them, pouring boiling water on them, or pulling them out by hand, as these methods work almost instantaneously. For a quick-acting solution that works within a few hours, you can use a commercial-grade herbicide like glyphosate or a DIY vinegar, salt, and dish soap mixture. While effective, be aware that commercial herbicides introduce chemicals into your lawn. The slowest method for killing weeds is to starve them of sunlight and nutrients using mulch or fabric covers.

Weeds may grow back when pulled out if the root is not completely removed. Invasive weeds can regrow from just a small portion of remaining root, so using a weed-pulling tool can help ensure you remove the entire root. Weeds may grow back faster if roots aren’t fully removed, and incomplete removal could cause them to spread as well.