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Squirrels hate not having access to secure shelter or food sources. Your best line of defense is to make your property less attractive by removing access to these things. There are chemical squirrel repellents, but these have mixed success. According to Pennsylvania State University, you can apply products containing the bittering agent denatonium saccharide to a squirrel's favorite fence, tree, or roof spots. However, you need to reapply repellents regularly, which aren’t scientifically proven effective.

A strong honeybee colony can usually fight off the aggressive presence of yellow jackets. However, weaker honeybee colonies with fewer workers are especially vulnerable to yellow jackets. If yellow jackets gain entry into a weakened honeybee colony, they can easily kill the honeybees and empty the hive of all its contents. 

Groundhogs have a strong aversion to powerful scents, including garlic, ammonia, vinegar, hot peppers like cayenne, and predator urine. Various herbs such as rosemary, lavender, basil, mint, sage, thyme, and oregano can also act as deterrents. You can strategically use these odors around your property by planting these crops near your garden and by the entrances to groundhog burrows. Commercially available repellents offer another option, and for best results, scent-based deterrents should be used alongside other preventive measures.

Skunks are nocturnal creatures, meaning they are primarily active at night, particularly around dusk and dawn. Their activity levels increase as the weather warms up, and they are generally dormant or inactive during the winter. Skunks are especially active during the spring months when they are foraging for fresh food and seeking mates. While they are typically not seen during the day, daytime activity is possible if a skunk is having trouble finding food, has babies to care for, or is severely ill.