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No, it's not really possible to completely prevent weed growth. Weeds are incredibly resilient—all they usually need is a tiny bit of dirt to sprout, so their eventual appearance is pretty much inevitable. However, you can definitely keep them at bay by getting rid of weeds as soon as you notice them. The longer you let them sit and grow roots, the more they'll spread.

Vinegar cannot tell the difference between weeds and desired grass types; it kills everything it touches. Only use a vinegar or vinegar-based solution if you are relatively confident that you can navigate around the plants and grasses you want to keep. Also, don’t spray vinegar on a windy day, or it will blow onto other plants.

The best way to keep voles from tunneling in your yard is to keep grass trimmed and bushes cut back from the ground at least 5 inches. Cleaning up yard debris, wood chip piles, and brush piles can also help keep voles at bay. If you notice vole activity, you can also remove bird feeders since these are a ready source of food for the tunneling rodents.

You should add 1 to 4 inches of mulch, depending on your garden type and needs. Keep in mind that no amount of mulch can completely prevent weeds, but a heavier coverage (closer to 4 inches) can suppress weeds enough that you are only seeing them sprout every few weeks. Finer mulch prevents weeds more effectively than large mulch, so if you’re using mulched leaves or shredded bark, 1 to 2 inches will likely suffice, while 3 to 4 inches is best for larger mulch, like bark chips or straw.