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Glyphosate and other non-selective herbicides can kill orchard grass, but they will also kill the surrounding plants. Also, not all areas allow the use of glyphosate due to its environmental impact—which the EPA describes as a "potential risk to terrestrial and aquatic plants and birds, and low toxicity to honeybees." Consider mechanical removal to target the plants specifically.

Buffalo grass is not a dense grass, so weeds can grow between the buffalo grass plants. However, as long as you don’t overwater your lawn, weeds have a hard time growing. If you do notice weeds, you can use granular herbicides that are safe for buffalo grass in early and late summer.

There are many options to eradicate weeds right down to the roots. Vinegar works, but it takes a week or so to do its thing, and the same goes for many commercially available herbicides. Boiled water is a quick way to kill off roots, or you can pull up weeds at the root.

The best time to hire a weed service company is in the early spring. This allows them to apply a pre-emergent weed killer that stops weeds from taking root, making maintenance for the rest of the season much easier. Following the initial spring application, a monthly service through the summer and early fall is a good idea for ongoing weed control. These regular treatments, combined with manual removal or spot treatment, should be sufficient to maintain a weed-free yard. Alternatively, you can hire a professional in the fall for the following year, as some companies may offer better rates on contracts signed before the busy spring season.